Get on The Fringe: Wednesday�s Festival list & other

Monday, 1 September 2008

Research Shows That Engineered Proteins Can 'Bypass' The Genetic Defect In Cystic Fibrosis

�By manipulating the machinery used by our cells for lineament control, researchers from the University of Pittsburgh have found a way to restore the function of cystic fibrosis (CF) air passage cells. This could significantly reduce the sticky mucous secretion that plugs the lungs of CF patients, which leads to antibiotic-resistant infections and premature death. The study, coming into court in the September 2008 print subject of The FASEB Journal (www.fasebj.org), is significant because it shows a raw way to manipulate the cellular timbre controls of all sorts of proteins which play a use in conditions ranging from aging to cancer.

"Our hope is that this put to work will put up new approaches for convalescent function from the protein whose inability to folding and function properly compromises the tone of animation and life expectancies of people with CF," aforementioned Raymond Frizzell, senior generator on the study. The researchers say, however, that it is too early to state exactly what other conditions this technique will affect.

Most people do not realise that when our bodies produce proteins, they sometimes make mistakes. Similar to what happens on assembly lines, these mistakes are rejected and prevented from being secondhand. In nearly people with CF, however, defective (i.e., variation) CFTR proteins made by airway epithelial cells could actually be beneficial if they were allowed to reach their final destination at cell surfaces. To help these mutant proteins (the {DELTA}F508 CF factor mutation) progress to cell surfaces, researchers developed a "steerer," made up of only a component part of the complete mutation protein, which is rejected instead. In airway epithelial cells taken from CF patients, the "distracted" airway cells allowed the complete {DELTA}F508 CFTR protein to evade the quality ascendence mechanisms that would have normally ruined it.

"Since this pivotal find of the CF factor nearly 20 years ago, researchers feature made more progress toward a cure than they had in thousands of years earlier," said Gerald Weissmann, MD, Editor-in-Chief of The FASEB Journal. "People with cystic fibrosis now live yearner than one time ever thought possible, and basic science breakthroughs like this peerless keep the trend ever upward."

According the U.S. Cystic Fibrosis Foundation, cystic fibrosis affects about 70,000 people worldwide. It is caused by a bad gene and its protein product, which causes the body to produce selfsame thick and sticky mucous secretion. This mucous secretion clogs the lungs and leads to life-threatening lung infections. It also blocks enzymes from the pancreas that requisite to break down and absorb food. Sixty old age ago, few children with cystic fibrosis lived to attend primary school. Today, the projecting median survival age is 37.

The FASEB Journal (hTTP://www.fasebj.org/) is published by the Federation of American Societies for Experimental Biology (FASEB) and is the most cited biology journal worldwide according to the Institute for Scientific Information. FASEB comprises 21 not-for-profit societies with more than 80,000 members, qualification it the largest alliance of biomedical research associations in the United States. FASEB advances biological science through collaborative advocacy for research policies that promote scientific advancement and education and lead to improvements in human health.

Article inside information: Chaperone displacement from mutant cystic fibrosis transmembrane conductance regulator restores its function in human airway epithelia. Fei Sun, Zhibao Mi, Steven B. Condliffe, Carol A. Bertrand, Xiaoyan Gong, Xiaoli Lu, Ruilin Zhang, Joseph D. Latoche, Joseph M. Pilewski, Paul D. Robbins, and Raymond A. Frizzell. FASEB J. 2008 22: 3255-3263. doi: 10.1096/fj.07-105338 http://www.fasebj.org/cgi/content/abstract/22/9/3255

Source: Cody Mooneyhan

Federation of American Societies for Experimental Biology

More info

Friday, 22 August 2008

Oral Contraceptives May Ease Suffering Of Women With Severe PMS, Clinical Trial

div

Latest News For Women's Health / Gynecology
Rights Groups In Uganda Call On Country To Pass Legislation To Curb Violence Against Women, Address HIV/AIDS Issues
21 Aug 2008

WSJ Examines Increasing Use, Concerns Over Breast Surgery Using Fat Augmented With Stem Cells
21 Aug 2008

Census Bureau Report Finds Women Having Fewer Children, Giving Birth Later In Life
21 Aug 2008

View more news...

Latest Videos for Women's Health
Cholesterol Management

Each year more than a million Americans have eye attacks. High cholesterol is a major risk factor for heart attack and stroke. Lifestyle changes and adherence to a treatment plan are important for cholesterol management...

Running Tips

Beginning a running program is a gradual process...

View more videos...

Most Popular Categories

cancer �
cardiovascular �
dermatology �
hiv �
nutrition �

diabetes �
obesity �
pediatrics �
psychology �
neurology �
alcohol �

urology �
breast cancer �
women's health �
infectious diseases �
respiratory �
sexual health �

gastrointestinal �
pain �
pregnancy �
bones �
medical devices �
medicare �

depression �
prostate �
smoking �
alzheimer's �
allergy �
sleep �

biology �
genetics �
eye health �
sports medicine �
hypertension �
abortion �

health insurance �
autism �
stem cell research �
adhd �
liver disease �
multiple sclerosis �

arthritis �
pharma industry �
seniors �
dentistry �
it �
nursing �

blood �
fertility �

More info

Wednesday, 6 August 2008

Iron & Wine add dates to fall trek

Iron & Wine [ ] protagonist Sam Beam has added a modern leg of full-band dates to his schedule following a go of acoustic solo shows in September.

The South Carolina-based singer/songwriter kicks off the headlining race Oct. 6 in Eugene, OR, next his solo dates opening for Glen Hansard and Marketa Irglova's Swell Season project. The 14-city trek runs through late November.

story_top_holder>

Beam also has a few major festival appearances lined up, including an Aug. 3

Haggard

Artist: Haggard

   Genre(s):
Metal: Gothic
   Rock: Sympho
   Folk: Folk-Rock

Discography:

Eppur Si Muove

Year: 2004
Tracks: 10

Awaking The Gods - Live In Mexico

Year: 2001
Tracks: 11

Awaking The Centuries

Year: 2000
Tracks: 12

And Thou Shalt Trust... The Seer

Year: 1997
Tracks: 8

Progressive

Year: 1994
Tracks: 5

Hadley Hockensmith

Artist: Hadley Hockensmith

   Genre(s):
New Age

Discography:

Heartsongs

Year: 1985
Tracks: 9

Thursday, 3 July 2008

Seinfeld Lawyer Hits Out At Cook's 'Bogus' Lawsuit

U.S. comic Jerry Seinfield's lawyer has hit out at the suit filed by U.S. chef Missy Chase Lapine - branding the case "bogus". Lapine sued Seinfeld's wife Jessica in January , stating her best selling cookbook Deceptively Delicious "brazenly plagiarised" her own book The Sneaky Chef. Both books describe how to hide healthy ingredients in children's foods. And after hearing of the legal action, Seinfeld appeared on U.S. TV show The Late Show and made jokes about the "vegetable plagiarism" facing the pair. Lapine added a defamation charge against funnyman Seinfeld over comments he made. And the star's legal team insist the comments were all to be taken in good humour, as Seinfeld is a well-known comedian and therefore is expected to be funny when being interviewed, and dismiss the lawsuit filed by Lapine as "absurd". Seinfeld's lawyer Orin Snyder tells America's E! news, "Nobody who was listening to Jerry Seinfeld thought he was doing anything but making very funny jokes. Nobody believed him to be stating facts. "Everyone understood him to be doing what he has done so well for so many years, which was telling jokes and entertaining. So the claim against him is frivolous and we have asked the court to dismiss it too." And Snyder insists the suit against the Seinfeld's is ridiculous, stating he find's it shocking Lapine believes she owns the copyright over age-old recipes. He adds, "This is a bogus lawsuit. It is absurd that this plaintiff would try to take credit for the idea of hiding healthy food in kids' meals. People have been using this obvious cooking technique in their kitchens for generations. Not surprisingly, it is easy to find countless other cookbooks and articles using this age-old idea that were written decades before this plaintiff claims to have invented it."

See Also